Thermo Fisher Scientific H-Ras Polyclonal Antibody
Human HRAS 단백질을 인식하는 rabbit polyclonal antibody로, WB, ELISA, IP에 적합합니다. 보존제가 없는 액상 형태이며, Protein A 및 항원 친화 크로마토그래피로 정제되었습니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1:5,000–1:10,000 |
| Immunoprecipitation (IP) | 4–6 µL/mg of lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human HRAS protein (Met1–Cys186) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787980 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide (final concentration 0.05%–0.1%) to prevent contamination.
This antibody specifically recognizes Human HRAS.
Target Information
H-Ras is a monomeric G protein functioning as a molecular switch that links receptor and nonreceptor tyrosine kinase activation to downstream signaling pathways, leading to various cytoplasmic or nuclear events. Mammalian cells contain three Ras proto-oncogenes—H-, K-, and N-Ras—encoding closely related proteins. Oncogenic mutations in Ras genes occur in approximately 30% of human cancers. Constitutive activation of Ras promotes proliferation and inhibits apoptosis.
- K-Ras mutations: common in pancreatic, colorectal, and non-small-cell lung carcinomas
- H-Ras mutations: common in bladder, kidney, and thyroid carcinomas
- N-Ras mutations: found in melanoma, hematological malignancies, and hepatocellular carcinoma
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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