Thermo Fisher Scientific H-Ras Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide (final concentration 0.05%–0.1%) to prevent contamination.
This antibody specifically recognizes Human HRAS.

Target Information

H-Ras is a monomeric G protein functioning as a molecular switch that links receptor and nonreceptor tyrosine kinase activation to downstream signaling pathways, leading to various cytoplasmic or nuclear events. Mammalian cells contain three Ras proto-oncogenes—H-, K-, and N-Ras—encoding closely related proteins. Oncogenic mutations in Ras genes occur in approximately 30% of human cancers. Constitutive activation of Ras promotes proliferation and inhibits apoptosis.

• K-Ras mutations: common in pancreatic, colorectal, and non-small-cell lung carcinomas
• H-Ras mutations: common in bladder, kidney, and thyroid carcinomas
• N-Ras mutations: found in melanoma, hematological malignancies, and hepatocellular carcinoma

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.