Thermo Fisher Scientific MMP3 Recombinant Mouse Monoclonal Antibody (rMMP3, 1730)
Recombinant mouse monoclonal antibody against human MMP3. Validated for IHC (Paraffin) applications with high specificity. Produced in HEK293 cells and purified via Protein A. Stored in PBS buffer with BSA and sodium azide at 4°C. For research ...
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- 4314-MSM4-P1
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | rMMP3, 1730 |
| Immunogen | Recombinant full-length human MMP3 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For Immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 min at 95°C, followed by cooling at room temperature for 20 min.
Target Information
MMP3 (stromelysin-1) belongs to the peptidase M10A subfamily. It is secreted as a pro-protein and activated by extracellular proteinase cleavage. MMP3 binds zinc and calcium ions and exhibits metallo-endopeptidase activity. The active enzyme degrades collagen, gelatin, fibronectin, and laminin, contributing to wound repair and tissue remodeling. Mutations in the gene are associated with coronary heart disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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