Thermo Fisher Scientific HSPA4 Recombinant Rabbit Monoclonal Antibody (23GB6195)
HSPA4 단백질을 표적하는 토끼 단클론 항체로, Western blot과 유세포분석에 적합합니다. HEK293F 발현 시스템에서 생산된 재조합 항체이며, 높은 특이성과 재현성을 제공합니다. PBS/glycerol 완충액에 보관되며 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:10,000 |
| Flow Cytometry (Flow) | 1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB6195 |
| Immunogen | A synthesized peptide derived from human Hsp20 (90–160AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
The HSP70 family is composed of four highly conserved proteins: HSP70, HSC70, GRP75, and GRP78.
HSP70 expression is strongly induced in response to heat stress. HSP70 and HSC70 play key roles in the cytosolic, endoplasmic reticulum, and mitochondrial import machinery, and are found in both the cytosol and nucleus of mammalian cells.
GRP78 is localized in the endoplasmic reticulum, where it receives imported secretory proteins and is involved in folding and translocation of nascent peptide chains.
GRP75 expression is restricted to the mitochondrial matrix and aids in the translocation and folding of nascent polypeptide chains of both nuclear and mitochondrial origin.
Members of the HSP70 family act as force-generating motors, relying on ATP hydrolysis for their activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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