Thermo Fisher Scientific MRPL12 Polyclonal Antibody
Thermo Fisher Scientific의 MRPL12 Polyclonal Antibody는 인간 MRPL12 단백질을 인식하는 고품질 항체로, WB, IHC, ICC/IF, IP 등 다양한 응용에 적합합니다. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공합니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific MRPL12 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:400 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Immunoprecipitation (IP) | 0.5–2 µL/mg of lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived Human MRPL12 fragment |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography, Protein A |
| Storage Buffer | PBS, pH 7 |
| Contains | 0.03% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2866914 |
Target Information
MRPL12 (mitochondrial ribosomal protein L12), also referred to as 5c5-2, L12mt, MRPL7 or RPML12, is a mammalian mitochondrial ribosomal protein involved in protein synthesis within the mitochondrion. MRPL12 is enhanced in growth-stimulated cells through transcriptional activation, suggesting a role as a translational regulator of mitochondrial mRNAs. Impairment of MRPL12 leads to reduced cell growth rate, decreased mitochondrial ATP production, and loss of oxidative phosphorylation. MRPL12 is cleaved during translocation across the mitochondrial membrane and exists as dimers that bind the large ribosomal subunit. It consists of 198 amino acids, belongs to the ribosomal protein L12P family, and is highly expressed in the colon.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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