Thermo Fisher Scientific NUP98 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 2–5 µg/mg lysate

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins.
The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both localized to the nucleoplasmic side of the NPC.
Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates.
The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL).
This gene is located in the imprinted gene domain of 11p15.5, an important tumor-suppressor region associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and several cancers (lung, ovarian, breast).
Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.