Thermo Fisher Scientific ARHGEF1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
YMRHLGVRTK SGDKKSGRNF FRKKVMGNRR SDEPAKTKKG LSSILDAARW NRGEPQVPDF RHLKAEVDAE KPGATDRKGG VGMPSRDRNI GAPGQDTPGV SLHPLSLDSP DREP

Highest antigen sequence identity to the following orthologs:

• Mouse: 84%
• Rat: 83%

Target Information

The Ras superfamily of GTPases, subdivided into Ras, Rho/Rac, Sar, Rab, ARF, and Ran subfamilies, controls multiple aspects of cell function such as cytoskeletal rearrangement, nuclear signaling, and cell growth. These GTPases act as regulated switches, toggling between an active GTP-bound and inactive GDP-bound form. Activation is catalyzed by guanine nucleotide exchange factors (GEFs).
Dbl-related proteins form a large family of structurally related molecules that catalyze GEF activity for specific members of the Ras family. Examples include FGD1, Lsc, RhoGEF p115, Lfc, Lbc, and Brx. Lsc, Lbc, and Lfc share sequence homology and show exchange activity toward Rho family GTPases. RhoGEF p115 catalyzes GEF activity for Rho but not Rac, Cdc42, or Ras GTPases.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.