Thermo Fisher Scientific HAS1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 80-390 of human HAS1 (NP_0015142) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:HAS1,uniProtId:Q92839-1,ncbiNodeId:9606,antigenRange:80-390,antigenLength:578,antigenImageFileName:PA5-87911_HAS1_Q92839-1_Rabbit.svg,antigenImageFileNamePDP:PA5-87911_HAS1_Q92839-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804497

Product Specific Information

Immunogen sequence: RVAAAARGPL DAATARSVAL TISAYQEDPA YLRQCLASAR ALLYPRARLR VLMVVDGNRA EDLYMVDMFR EVFADEDPAT YVWDGNYHQP WEPAAAGAVG AGAYREVEAE DPGRLAVEAL VRTRRCVCVA QRWGGKREVM YTAFKALGDS VDYVQVCDSD TRLDPMALLE LVRVLDEDPR VGAVGGDVRI LNPLDSWVSF LSSLRYWVAF NVERACQSYF HCVSCISGPL GLYRNNLLQQ FLEAWYNQKF LGTHCTFGDD RHLTNRMLSM GYATKYTSRS RCYSETPSSF LRWLSQQTRW SKSYFREWLY N; Positive Samples: U-87MG, DU145, Mouse skeletal muscle; Cellular Location: Membrane, Multi-pass membrane protein

Target Information

Hyaluronic acid is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.