Thermo Fisher Scientific TIM-1 Monoclonal Antibody (12B1C8H3)

Applications and Tested Dilution

• ELISA (ELISA): 1:250–1:2,000

Product Specifications

Product Specific Information

• Specificity: Human HAVCR1/TIM1/KIM1

Target Information

CD365, also known as T-cell immunoglobulin and mucin domain 1 (Tim-1), is a type I surface glycoprotein composed of an extracellular N-terminal immunoglobulin V-like domain, a mucin domain, and a short cytoplasmic tail.
The endogenous ligand for CD365 is Tim-4. CD365 functions as a cellular receptor or co-receptor for several viruses including hepatitis A and C viruses, Ebola virus, Marburg virus, Dengue virus, Zika virus, West Nile virus, and Japanese encephalitis virus.
Virus binding occurs via phosphatidylserine exposed on viral envelopes. Polymorphisms in the human CD365 gene (HAVCR1) are associated with infection susceptibility and disease severity. CD365 also plays a role in T cell co-stimulation and is primarily expressed in epithelial cells, with high expression in A549, 769-P, and Caco-2 cell lines. A soluble form of CD365 can be generated by metalloproteinase-mediated proteolytic cleavage of the surface protein.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.