Thermo Fisher Scientific SETD7 Monoclonal Antibody (7C1B7E1)
Human SETD7 단백질을 인식하는 Mouse monoclonal antibody로, ELISA에 적합합니다. Protein A로 정제된 액상 형태이며, -20°C에서 보관합니다. Histone H3 Lys-4 단일 메틸화를 인식하여 전사 활성화 연구에 활용됩니다.
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Applications
- ELISA (ELISA)
Tested Dilution: 1:1,000–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 7C1B7E1 |
| Immunogen | Recombinant Human SETD7 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2912158 |
Product Specific Information
- Specificity: Human SETD7 / SET7 / 9
Target Information
Histone methyltransferase that specifically monomethylates Lys-4 of histone H3.
H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation.
Plays a central role in the transcriptional activation of genes such as collagenase or insulin.
Recruited by IPF1/PDX-1 to the insulin promoter, leading to transcriptional activation.
Has methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K motif in substrate proteins.
Monomethylates Lys-189 of TAF10, increasing its affinity for RNA polymerase II.
Monomethylates Lys-372 of p53/TP53, stabilizing p53/TP53 and enhancing p53/TP53-mediated transcriptional activation.
[Source: UniProt]
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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