Thermo Fisher Scientific GAS2 Polyclonal Antibody
GAS2 단백질을 인식하는 토끼 폴리클로날 항체로, IHC, ICC, ELISA 등 다양한 응용에 적합합니다. Human, Mouse, Rat 시료에 반응하며, Protein A로 정제된 1 mg/mL 액상 형태입니다. 세포골격 및 세포사멸 연구에 유용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human GAS2 (amino acids 141–240) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01 M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Gas2 is a 313 amino acid protein encoded by the human GAS2 gene. It plays a role in apoptosis as a substrate for caspases, particularly caspase-3 and caspase-7, which cleave Gas2 at Asparagine 278. This cleavage induces actin cytoskeleton rearrangement and morphological changes during apoptosis. Gas2 is also involved in membrane ruffling and is phosphorylated during the G0–G1 transition phase. It co-localizes with actin fibers at the cell border and along stress fibers in growth-arrested fibroblasts. Expression is highest in liver, lung, and kidney.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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