Thermo Fisher Scientific Ras (K117N Mutant) Polyclonal Antibody
Ras (K117N 변이체)에 특이적인 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot에 적합하며, Human 반응성 확인됨. 고순도 항원 친화 크로마토그래피 정제, 액상 형태로 제공. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
- Western Blot (WB)
Tested Dilution: 1:1,000–1:10,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human Ras (K117N Mutant Specific). The exact sequence is proprietary. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2736504 |
Product Specific Information
- Positive Control: Human Ras (K117N Mutant specific)-transfected 293T whole cell extracts
- Predicted Reactivity: Mouse (100%), Rat (100%), Dog (100%), Pig (100%), Chicken (100%), Bovine (100%), Guinea pig (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Ras is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. The process of shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in Ras gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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