Thermo Fisher Scientific Legumain Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. The enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.