Thermo Fisher Scientific MAVS Polyclonal Antibody
MAVS 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, 인간 및 마우스 반응성을 보입니다. Western blot, IHC, ICC/IF 등 다양한 응용에 적합하며, 고순도 친화 크로마토그래피 정제 제품입니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 4 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:50 | View 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues at the carboxyl terminus of human MAVS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 71 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10979584 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway relies on members of the Toll-like receptor (TLR) family, while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA to trigger the immune response.
MAVS is a mitochondrial membrane protein essential in IFN beta signaling, recruiting IRF-3 to RIG-I for activation of NF-kappa-B. It interacts with innate immune components such as TRIF, TRAF2, TRAF6, and kinases IKK-alpha, IKK-beta, and IKK-iota through its C-terminal region.
Cleavage of this region by Hepatitis C virus (HCV) protease enables HCV to evade the host immune system. Multiple isoforms of MAVS are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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