Thermo Fisher Scientific DCP2 (Decapping mRNA 2) Monoclonal Antibody (PCRP-DCP2-1D6)

Thermo Fisher Scientific DCP2 (Decapping mRNA 2) Monoclonal Antibody (PCRP-DCP2-1D6)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Antibody stability: 24 months
• Positive control: MCF7, Daudi, or Jurkat cells
• Cellular localization: Predominantly cytoplasmic (processing bodies, PB), minor nuclear presence
• Specificity comments:
  The major pathway of eukaryotic mRNA decay involves deadenylation-dependent decapping followed by 5′ exonucleolytic degradation. Human decapping enzyme 2 (hDcp2) is an mRNA decapping enzyme with intrinsic decapping activity. In nonsense-mediated decay, the hDcp1–hDcp2 complex may be recruited to mRNAs containing premature termination codons by Upf proteins. The decapping activator complex (Lsm1p–7p) enhances recruitment and co-immunoprecipitation of the decapping complex with mRNA. Dcp2 hydrolyzes methylated capped RNA to release m7GDP, aiding mRNA degradation. Dcp1 and Dcp2 co-localize in the cytoplasm, consistent with their role in mRNA decay.
• Predicted to react with: Mouse and Rat

Target Information

Decapping protein 2 (DCP2) is the major mRNA decapping enzyme in eukaryotic cells, belonging to the Nudix hydrolase superfamily. It catalyzes hydrolysis of nucleoside diphosphate-linked substrates and is widely expressed in various tissues, with highest levels in testis and brain.
Decapping is a key step in mRNA degradation, regulating gene expression and RNA turnover.

Usage Restriction

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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