Thermo Fisher Scientific FAT4 Polyclonal Antibody
Human FAT4 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:25~1:100 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며 PBS 버퍼(40% glycerol)로 보관. -20°C에서 저장하며 연구용으로 적합.
- 판매단위
- pk
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:25–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues near the C-terminal of human FAT tumor suppressor homolog 4 (Drosophila) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.7 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2636040 |
Product Specific Information
The antibody detects endogenous levels of total FAT4 protein.
Target Information
FAT1, FAT2, FAT3, and FAT4 are human homologs of Drosophila Fat, which is involved in tumor suppression and planar cell polarity (PCP). FAT4 undergoes proteolytic cleavage by Furin and is predicted to undergo a second cleavage by secretase to release the intracellular domain (ICD). FAT4 directly interacts with MPDZ/MUPP1 to recruit membrane-associated guanylate kinase MPP5/PALS1. FAT4 plays a role in maintaining PCP and inhibiting cell proliferation.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-50587_FAT4_Q6V0I7-1_Rabbit.svg, PA5-50587_FAT4_Q6V0I7-1_Rabbit_PDP.jpeg)
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