Thermo Fisher Scientific PUM1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000
• Publications: References

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200
• Publications: References

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total PUM1.

Target Information

PUM1 (pumilio homolog 1) is a sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3′-UTR of mRNA targets. It belongs to the PUF family, which consists of evolutionarily conserved RNA-binding proteins.
PUM1 binds to the RNA consensus sequence known as the Pumilio Response Element (PRE), 5′-UGUANAUA-3′, related to the Nanos Response Element (NRE).
It mediates post-transcriptional repression by recruiting the CCR4-POP2-NOT deadenylase complex, leading to translational inhibition and mRNA degradation.
Mutations in the PUM1 gene can result in spinocerebellar ataxia 47.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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