Thermo Fisher Scientific CD72 Polyclonal Antibody
CD72 단백질을 인식하는 토끼 폴리클로날 항체로 인간 및 마우스 시료에 반응. Western blot 및 IHC(파라핀) 분석에 적합. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CD72 (Accession P21854), corresponding to amino acid residues R176–C226 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852324 |
Product Specific Information
Antibody detects endogenous levels of total CD72.
Target Information
CD72 is a transmembrane glycoprotein expressed as a homodimer, primarily in B cells and also in other antigen-presenting cells such as dendritic cells and macrophages. Through one of its immunoreceptor tyrosine-based inhibitory motifs (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72, resulting in dissociation of SHP-1 from CD72 and enabling B cell activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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