Thermo Fisher Scientific Phospho-CaMKII alpha/beta/delta (Thr305) Polyclonal Antibody
CaMKII α/β/δ 인산화(Thr305) 특이적 폴리클로날 항체로, Western blot과 IHC(Paraffin)에 사용 가능. Rabbit IgG 기반 비결합형 액상 항체이며, 세포 신호전달 및 단백질 인산화 연구에 적합. Thermo Fisher Scientific 제공.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human CaMKII around the phosphorylation site of Thr305 (I-L-TP-T-M) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554840 |
Target Information
The Ca²⁺/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases including CaMKI, CaMKII, and CaMKIV.
CaMKII is an ubiquitously expressed serine/threonine protein kinase activated by Ca²⁺ and calmodulin (CaM), implicated in regulation of the cell cycle and transcription.
There are four CaMKII isozymes—alpha, beta, gamma, and delta—which may or may not be co-expressed in the same tissue type.
CaMKII alpha is autophosphorylated on Thr286 upon Ca²⁺/CaM complex binding to the autoinhibitory domain of CaMKII. This process, called Ca²⁺/CaM trapping, is thought to be involved in synaptic encoding of information.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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