Thermo Fisher Scientific SUMO-1 Monoclonal Antibody (SPM571)
SUMO-1 단백질 검출용 단일클론 항체로, Western blot, IHC, ICC, Flow cytometry 등에 사용 가능. 인간 단백질에 반응하며, 단백질 A/G로 정제된 액상 형태. 4°C에서 보관하며 연구용으로만 사용.
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- 7341-MSM1X-Px (2개 옵션)
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카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific SUMO-1 Monoclonal Antibody (SPM571)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SPM571 |
| Immunogen | Recombinant human SUMO1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
SUMO1 is a ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Its covalent attachment via an isopeptide bond requires activation by the E1 complex (SAE1-SAE2) and linkage to the E2 enzyme (UBE2I), which can be promoted by E3 ligases such as PIAS1-4, RANBP2, or CBX4. This post-translational modification plays a crucial role in cellular processes including nuclear transport, DNA replication and repair, mitosis, and signal transduction. SUMO1 is involved in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains may undergo polyubiquitination, signaling proteasomal degradation of modified proteins. Additionally, SUMO1 may regulate genes involved in palate development, and mutations in the gene are associated with non-syndromic orofacial cleft 10.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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