Thermo Fisher Scientific SUMO-1 Monoclonal Antibody (SUMO1/1188)
SUMO1 단백질을 특이적으로 인식하는 단클론 항체로, Western blot, IHC, ICC/IF, Flow Cytometry 등 다양한 응용 가능. 인간 및 랫트 반응성. Recombinant SUMO1을 면역원으로 제작된 Mouse IgG1 항체. 연구용으로만 사용.
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- 7341-MSM2-P1ABX
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SUMO1/1188 |
| Immunogen | Recombinant human SUMO1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Predicted to show a broad species reactivity.
Target Information
SUMO1 is an ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond requires activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, promoted by E3 ligases such as PIAS1-4, RANBP2, or CBX4. This post-translational modification on lysine residues plays a crucial role in cellular processes such as nuclear transport, DNA replication and repair, mitosis, and signal transduction. SUMO1 is involved in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains can be polyubiquitinated, signaling proteasomal degradation of modified proteins. SUMO1 may also regulate genes involved in palate development, and mutations can result in non-syndromic orofacial cleft 10.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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