Thermo Fisher Scientific GZMB/GZMH Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

1:100-1:500

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human GZMB(Accession P10144), corresponding to amino acid residues M1-G50. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:GZMB/GZMH,uniProtId:P10144-1,ncbiNodeId:9606,antigenRange:1-50,antigenLength:247,antigenImageFileName:PA5-115323_GZMBGZMH_P10144-1_Rabbit.svg,antigenImageFileNamePDP:PA5-115323_GZMBGZMH_P10144-1_Rabbit_PDP.jpeg,sortOrder:1},{targetFamily:GZMB/GZMH,uniProtId:P20718-1,ncbiNodeId:9606,antigenRange:1,antigenLength:246,antigenImageFileName:PA5-115323_GZMBGZMH_P20718-1_Rabbit.svg,antigenImageFileNamePDP:PA5-115323_GZMBGZMH_P20718-1_Rabbit_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2899959

Product Specific Information

Antibody detects endogenous levels of total Granzyme B/H.

Target Information

GZMB/GZMH are members of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.