Thermo Fisher Scientific GZMB/GZMH Polyclonal Antibody
GZMB/GZMH 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC(P), ICC/IF 등에 사용 가능. Human, Mouse, Rat 반응성. 액상 형태로 1 mg/mL 농도, PBS+50% glycerol buffer. Affinity chromatography로 정제됨. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human GZMB (Accession P10144), corresponding to amino acid residues M1–G50 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899959 |
Product Specific Information
This antibody detects endogenous levels of total Granzyme B/H.
Target Information
GZMB/GZMH are members of the granzyme subfamily of proteins, belonging to the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs), and is proteolytically processed to generate the active protease that induces target cell apoptosis.
This protein also processes cytokines and degrades extracellular matrix proteins, contributing to chronic inflammation and wound healing. Expression may be elevated in human patients with cardiac fibrosis.
[Provided by RefSeq, Sep 2016]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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