Thermo Fisher Scientific P4HB/PDI Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt.
• Based on 100% sequence identity, predicted to react with Rat, Bovine, and Orangutan.

Target Information

Protein disulfide isomerase (PDI) is a multifunctional protein that catalyzes the formation, breakage, and rearrangement of disulfide bonds.
At the cell surface, it acts as a reductase that cleaves disulfide bonds of proteins attached to the cell, potentially causing structural modifications of exofacial proteins.
Inside the cell, PDI forms or rearranges disulfide bonds of nascent proteins.
At high concentrations, it functions as a chaperone inhibiting aggregation of misfolded proteins, while at low concentrations, it facilitates aggregation (anti-chaperone activity).
PDI may interact with other chaperones in structural modification of the TG precursor in hormone biogenesis.
It also serves as a structural subunit of enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein (MTTP).
Acts as a receptor for LGALS9, retaining P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the redox state, and enhancing cell migration.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.