Thermo Fisher Scientific CD45RA Monoclonal Antibody (MEM-56), FITC
인간 CD45RA를 인식하는 Mouse IgG2b 모노클로날 항체로 FITC 형광 표지됨. Flow Cytometry에 적합하며 높은 형광 효율과 수용성 제공. PBS/BSA 버퍼에 보관하며 4°C 암소 저장. 다양한 형광 형식으로도 제공.
- 카탈로그번호
- MHCD45RA01
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific CD45RA Monoclonal Antibody (MEM-56), FITC
Applications
- Flow Cytometry (Assay-dependent)
관련 논문
- Flow Cytometry: 8편
- Miscellaneous PubMed: 1편
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-56 |
| Immunogen | Human CD45RA |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Purification | Purified |
| Storage Buffer | PBS with 4 mg/mL BSA |
| Contains | 0.1% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10373858 |
Additional Formats
- APC
- Pacific Blue
- PE
- PE-Cyanine5.5
- PE-Texas Red
- Qdot 605
- Qdot 655
- Custom conjugation available
Product Specific Information
FITC conjugates provide high absorptivity, excellent fluorescence quantum yield, and good water solubility, making them ideal for flow cytometry applications.
Target Information
CD45RA is an isoform of the CD45 complex expressed selectively among lymphoid cell subtypes. CD45 (leukocyte common antigen) is a receptor-type protein tyrosine phosphatase present in all nucleated hematopoietic cells and constitutes about 10% of lymphocyte surface proteins. It regulates Src-family kinases, influences antigen signaling, and plays a role in lymphocyte development.
CD45 isoforms differ by alternative splicing in extracellular domains but share identical transmembrane and cytoplasmic regions. These isoforms vary in membrane domain localization and expression depending on cell type and physiological state.
Beyond immunoreceptor signaling, CD45 modulates integrin-mediated pathways and participates in apoptosis-related DNA fragmentation. It is expressed in hematopoietic cells except mature erythrocytes and absent in other differentiated tissues.
CD45 dysfunction is associated with severe combined immunodeficiency and Hepatitis C.
Analyte Specific Reagent
For research use only. Not for diagnostic or therapeutic applications.
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