Thermo Fisher Scientific p27Kip1 (Mitotic Inhibitor/Suppressor Protein) Monoclonal Antibody (SX53G8)
p27Kip1 단백질을 인식하는 SX53G8 클론의 마우스 모노클로날 항체. 인간, 마우스, 원숭이, 랫트 반응성. IHC, ICC/IF, Flow Cytometry 등 다양한 응용 가능. 단백질 A/G로 정제된 액상 형태, PBS 버퍼에 보존제 없음.
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Thermo Fisher Scientific p27Kip1 (Mitotic Inhibitor/Suppressor Protein) Monoclonal Antibody (SX53G8)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 0.25–0.5 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SX53G8 |
| Immunogen | Purified GST-p27 fusion protein of human origin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
- CF 488 conjugated format available
- Custom conjugation upon request
Target Information
p27 Kip1 functions as a negative regulator of G1 phase progression and mediates TGFβ-induced G1 arrest. It inhibits cyclin E- and cyclin A-CDK2 complexes and interacts with cyclin D-CDK4 complexes, influencing their activation depending on phosphorylation state. The protein (~27 kDa) undergoes CDK-dependent phosphorylation and ubiquitination by SCF complexes, which triggers its degradation and enables cellular transition from quiescence to proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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