Thermo Fisher Scientific PROZ Monoclonal Antibody (OTI3A11), TrueMAB
인간 PROZ 단백질을 인식하는 Mouse monoclonal antibody (OTI3A11). Western blot에 최적화되어 있으며, 액상 형태로 제공됩니다. PBS, BSA, glycerol 함유 buffer에 보관하며, -20°C에서 안정적입니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3A11 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 115–400 of human PROZ produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
PROZ (Protein Z) is a vitamin K-dependent plasma glycoprotein, approximately 62 kDa and 396 amino acids in length. It contains a Gla-rich region, two EGF-like domains, and a trypsin-like domain but lacks the catalytic serine residue typical of active serine proteases.
Protein Z participates in the coagulation cascade and is structurally related to factors VII, IX, X, and protein C. It binds to phospholipid surfaces via vitamin K-dependent carboxyglutamate residues. Its primary role is to facilitate the degradation of factor Xa by protein Z-related protease inhibitor (ZPI), enhancing the reaction rate up to 1000-fold. Deficiency in PROZ may be associated with either thrombotic or bleeding tendencies, though its physiological role is inhibitory.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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