Thermo Fisher Scientific Thyroglobulin Polyclonal Antibody
사람 Thyroglobulin을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:200~1:500 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공. PBS 기반 완충액에 40% 글리세롤 포함, 4°C 또는 -20°C에서 보관.
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Applications
Tested Application & Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human TG. Recombinant protein control fragment (Product #RP-100475) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2789195 |
Product Specific Information
Immunogen sequence:
KMCSADYADL LQTFQVFILD ELTARGFCQI QVKTFGTLVS IPVCNNSSVQ VGCLTRERLG VNVTWKSRLE DIPVASLPDL HDIERALVGK DLLGRFTDLI QSGSFQLHLD SKTFPAETIR FLQGDHFGTS PRTWFGCSEG FYQVLTSEAS QDGLGCVKCP EGS
Target Information
The human thyroglobulin (hTg) is a high molecular weight glycoprotein (605 kDa) found in thyroid follicular cells. It plays a central role in the uptake, incorporation, and regulated biosynthesis of thyroid hormones T4 and T3.
Thyroid disorders are often autoimmune in origin, and anti-thyroglobulin autoantibodies were the first to be discovered. Anti-hTG is present in all thyroid autoimmune diseases (Hashimoto thyroiditis, Graves disease), with the highest levels observed in Hashimoto thyroiditis.
Anti-hTG is also characteristic of thyroid cancer, and its measurement can be used for monitoring cancer patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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