Thermo Fisher Scientific Phospho-TAK1 (Thr187) Polyclonal Antibody
인산화된 TAK1(Thr187)을 특이적으로 인식하는 Rabbit Polyclonal 항체로, Human에 반응하며 DB 등 다양한 응용에 사용 가능. KLH 결합 합성 phosphopeptide를 면역원으로 사용하며, Protein A 및 항원 친화 크로마토그래피로 정제됨. 연구용으로만 사용.
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Thermo Fisher Scientific Phospho-TAK1 (Thr187) Polyclonal Antibody
Applications
- Dot blot (DB)
Tested Dilution: 1:500
Publications: - [References not available]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T187 of human MAP3K7 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10980241 |
Product Specific Information
This antibody is predicted to react with bovine, mouse, and rat based on sequence homology.
Target Information
TAK1 (also known as MAP3K7) is a serine/threonine kinase involved in multiple signaling pathways. Initially identified as a TGF-β-activated kinase, TAK1 interacts with TGF-β receptor and TRAF6 to modulate activation of JNK and p38. It also participates in signaling through Wnt, BMP, and activin pathways and responds to thyroid hormone, osmotic stress, endothelin, and ephrine.
TAK1 promotes wound healing by activating von Hippel-Lindau tumor suppressor expression and repressing PDGF-B, integrin β1, and integrin β5. It plays a critical role in IKK activation in pathways including IL-1, IL-6, IL-18, TNF, CD40, TLR, and RIG-I. Activation involves TAB2/3 binding, polyubiquitination, and TAK1 autophosphorylation at Thr178, Thr184, Thr187, and Ser192, leading to phosphorylation of IKK-β. TAK1 also represses human telomerase reverse transcriptase, implicating it in cell lifespan regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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