Thermo Fisher Scientific Nectin 3 Polyclonal Antibody
인간, 생쥐, 랫트에서 반응하는 Nectin 3 폴리클로날 항체로, WB 및 ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 1 mg/mL 농도입니다. 세포 간 접착 분자 연구 및 Nectin-3 단백질 검출에 활용됩니다.
- 카탈로그번호
- PA551095
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from the internal region of human Nectin 3 (aa 311–360) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.5% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2636543 |
Product Specific Information
Nectin 3 / CD113 Polyclonal Antibody detects endogenous levels of Nectin 3 / CD113 protein.
Target Information
Nectin-3 is an 83 kDa type I transmembrane glycoprotein. Nectin, originally isolated as poliovirus receptor-related protein (PRR), is a cell-cell adhesion molecule of the immunoglobulin superfamily.
Nectins are calcium-independent immunoglobulin-like cell-cell adhesion molecules consisting of four members: nectin 1–4.
They interact homophilically and heterophilically to form various cell-cell junctions, including cadherin-based adherens junctions, synaptic junctions, and Sertoli cell-spermatid junctions.
Nectin-2 and Nectin-3 are ubiquitously expressed, while Nectin-1 is abundant in the brain. Nectin-3 exists in three isoforms (alpha, beta, gamma), with Nectin-3 alpha being the largest.
It is predominantly expressed in testis and placental tissues and interacts with afadin, an actin-binding protein, at cadherin-based junctions.
The ectodomains of Nectin-3 and CD155 (Poliovirus Receptor) show strong affinity to each other.
Injection of antibody 103-A1 into seminiferous tubules disrupts actin filaments in Sertoli cells and causes exfoliation of maturing spermatids.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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