Thermo Fisher Scientific FN1 Monoclonal Antibody (OTI1G2), TrueMAB
Human FN1 단백질(아미노산 32–307)을 항원으로 제작된 마우스 단클론 항체로, WB 및 IHC(P) 실험에 적합합니다. 비결합형 액상 형태이며, 고순도 친화 크로마토그래피로 정제되었습니다. 세포 부착, 이동 및 암 관련 연구에 활용됩니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1G2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 32–307 of human FN1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Fibronectin is a disulfide-bonded dimer with a molecular weight range of 230–250 kDa. In the extracellular matrix of connective tissues and vessels, fibronectin exists as an insoluble, cross-linked protein forming high molecular mass polymers. It is abundant during embryonic development and tissue remodeling and also found as a soluble plasma protein.
Fibronectin consists of repeating modules forming domains that interact with fibronectin itself, other matrix components (e.g., collagen, heparin), and cell surface receptors (e.g., integrins). It plays a critical role in cell adhesion and migration, including processes such as embryogenesis, wound healing, blood coagulation, host defense, and metastasis.
Fibronectin expression is elevated in non-small cell lung carcinoma, where its interaction with carcinoma cells enhances tumorigenicity and resistance to apoptosis induced by chemotherapeutic agents. The FN1 gene undergoes alternative splicing, potentially generating up to 20 transcript variants, though not all have been fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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