Thermo Fisher Scientific ATG14 Polyclonal Antibody
ATG14 단백질을 표적으로 하는 Thermo Fisher Scientific의 폴리클로날 항체. Western blot 및 IHC에 적합하며, 사람, 생쥐, 랫트 반응성. 고순도(>95%) 항원 친화 크로마토그래피 정제. 연구용으로만 사용 가능.
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Thermo Fisher Scientific ATG14 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to amino acids 152–406 of Human ATG14 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2804070 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
ATG14 (Autophagy related protein homolog 14) is encoded by the ATG14 gene located on chromosome 14 in humans. It is also known as ATG14L or BARKOR (Beclin 1-associated autophagy-related key regulator).
Autophagy is an evolutionarily conserved process that recycles misfolded cellular proteins and degrades dysfunctional organelles. It is induced as a response to nutrient stress, involving the formation of autophagosomes, fusion with lysosomes, and formation of autophagolysosomes.
The Class III PI3-Kinase Vps34 and its interacting partner Beclin 1 form a complex that includes ATG14 (type 1) or UVRAG (type 2). ATG14 guides the type 1 complex to the preautophagosomal structure (PAS) and is critical for the initiation of autophagosome formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: PA5-87326_ATG14_Q6ZNE5-1_Rabbit.svg, PA5-87326_ATG14_Q6ZNE5-1_Rabbit_PDP.jpeg)
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