Thermo Fisher Scientific NOD2 Polyclonal Antibody
NOD2 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot, IHC, ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. 합성 펩타이드 항원 기반, 액상 형태로 제공되며 -20°C 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NOD2 (Accession Q9HC29), corresponding to amino acid residues A110–G160 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853627 |
Product Specific Information
Antibody detects endogenous levels of total NOD2.
Target Information
NOD2 is a member of the apoptosis-regulating protein family that includes caspase recruitment domains, as well as Apaf-1 and NOD1. It contains two N-terminal CARDs, a nucleotide-binding domain (NBD), and multiple C-terminal leucine-rich repeats (LRRs).
NOD2 is expressed in monocytes (whereas NOD1 is expressed in multiple tissues). It plays a role in regulating NF-kappaB, acts as an intracellular receptor for bacterial lipopolysaccharides, and contributes to inflammatory bowel disease (IBD) and Crohn’s disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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