Thermo Fisher Scientific CST2 Monoclonal Antibody (OTI5C2), TrueMAB

Applications

ELISA

• Tested Dilution: 1:100–1:1,000

Product Specifications

Target Information

The cystatin superfamily is a well-established family of cysteine protease inhibitors.
Cystatins A and B (type 1) are mainly intracellular; cystatins C, D, E/M, F, G, S, SN, and SA are extracellular (type 2); and the kininogens are type 3 cystatins found in intravascular proteins.

All true cystatins inhibit cysteine peptidases of the papain family (e.g., cathepsins) and some also inhibit legumain family enzymes.
Cystatin SA, S, and SN are primarily found in saliva, while S and SN can also be expressed in tears, urine, and seminal fluid.
Cystatin C is expressed in brain, thymus, ovary, epididymis, and vas deferens.
Cystatin D protects against proteinases in the oral cavity, while Cystatin E/M and F moderate inhibition of cathepsin proteins.
Fetuins, part of the cystatin superfamily, are secretable proteins influencing osteogenesis, bone resorption, and regulation of insulin and hepatocyte growth factor receptors.
High and low molecular weight kininogens inhibit thrombin- and plasmin-induced thrombocyte aggregation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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