Thermo Fisher Scientific Amyloid Precursor Protein Polyclonal Antibody
Thermo Fisher의 Amyloid Precursor Protein 다클론 항체로, 인간·마우스·랫트 시료에 반응합니다. Western blot과 IHC에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. APP 관련 신경질환 연구용으로 권장됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (IHC) | 2.5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | An 18 amino acid synthetic peptide within amino acid 30–80 of human APP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152361 |
Product Specific Information
- A suggested positive control is mouse brain tissue lysate.
- PA5-20711 can be used with blocking peptide PEP-0826.
Target Information
Amyloid Precursor Protein (APP), also known as Amyloid beta precursor protein, functions as a cell surface kinesin I membrane receptor mediating the axonal transport of beta-secretase and presenilin 1. APP plays a crucial role in neurite growth, neuronal adhesion, and axonogenesis. It is a 100–140 kDa transmembrane glycoprotein with multiple isoforms resulting from alternative splicing.
Proteolytic cleavage of APP by beta- and gamma-secretases generates beta amyloid, the main component of senile plaques—one of the key histopathologic features of Alzheimer’s disease. Abnormal regulation and processing of APP are also implicated in Down’s syndrome, early-onset familial Alzheimer’s disease, and cerebral hemorrhage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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