Thermo Fisher Scientific OGG1 Recombinant Rabbit Monoclonal Antibody (JA18-13)
OGG1 단백질을 인식하는 재조합 토끼 단일클론 항체로, Western blot 및 IHC(P) 분석에 적합합니다. 높은 특이성과 일관된 로트 간 재현성을 제공하며, 인간 시료에 반응합니다. 단백질 A로 정제된 액상 형태로 공급됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JA18-13 |
| Immunogen | Synthetic peptide within Human OGG1 (aa 296–345) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2810112 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The specific antibody DNA sequences from immunoreactive rabbits are cloned, and individual clones are screened to select the best candidates for production.
Advantages include:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
8-hydroxyguanine is a form of oxidative DNA damage caused by free radicals, leading to G:C to T:A transversions.
In E. coli, three DNA repair enzymes prevent the mutagenic effects of 8-hydroxyguanine. One of these, MutM, has yeast (yOgg1) and human (hOgg1) homologues.
hOgg1 proteins efficiently remove 8-hydroxyguanine opposite pyrimidines from DNA and cleave AP sites similarly to bacterial and yeast enzymes.
Genetic control of DNA repair influences cancer susceptibility. The hOgg1 gene is mapped to 3p26.2, a region with loss of heterozygosity (LOH) in various cancers, notably lung cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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