Thermo Fisher Scientific RIPK2 Monoclonal Antibody (3D9)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
LQPGIAQQWI QSKREDIVNQ MTEACLNQSL DALLSRDLIM KEDYELVSTK PTRTSKVRQL LDTTDIQGEE FAKVIVQKLK DNKQMGLQPY PEILVVSRSP SLNLLQNKSM

Target Information

RIPK2 is a serine/threonine kinase involved in cell activation, proliferation, differentiation, and apoptosis. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize, and recruit RIPK2 through CARD-CARD domains.
RIPK2 contributes to the tyrosine phosphorylation of ARHGEF2 via Src kinase, leading to NF-κB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes Lys-63-linked polyubiquitination by E3 ligases XIAP, BIRC2, and BIRC3.
The polyubiquitinated protein mediates recruitment of MAP3K7/TAK1 to IKBKG/NEMO, induces Lys-63-linked polyubiquitination of IKBKG/NEMO, and activates IKBKB/IKKB. NF-κB then translocates to the nucleus, activating transcription of genes involved in immune response, growth control, and apoptosis protection.
RIPK2 also plays a role in T-cell receptor engagement by promoting BCL10 phosphorylation and subsequent NF-κB activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.