Thermo Fisher Scientific LGI1 Monoclonal Antibody (N283/7), PerCP
LGI1 단백질을 인식하는 Mouse Monoclonal Antibody (Clone N283/7)로 PerCP 형광 표지된 제품. Western blot, IHC, ICC 등 다양한 응용에 사용 가능. Human, Mouse, Rat 반응성. 고순도 Protein G 정제, 4°C 보관.
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Applications
- Western Blot (WB): 1:1,000
- Immunohistochemistry (IHC): Assay-dependent
- Immunocytochemistry (ICC/IF): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | N283/7 |
| Immunogen | Fusion protein amino acids 37–113 (LRRNT domain and first LRR repeat) of mouse LGI1 |
| Conjugate | PerCP |
| Excitation/Emission Max | 482 / 675 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 95.64 mM phosphate / 2.48 mM MES, pH 7.4, with 0.5 M EDTA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2932133 |
Additional Formats
Product Specific Information
- Rat: 100% identity (77/77 amino acids identical)
- Human: 98% identity (76/77 amino acids identical)
- ~50% identity with LGI2, LGI3, and LGI4
- 1 µg/mL of MA5-45679 detects LGI1 in 20 µg of rat brain lysate by colorimetric immunoblot using Goat anti-mouse IgG:HRP as secondary antibody
- Detects approximately 60 kDa
- Formerly sold as clone S283-7
Target Information
LGI1 (Leucine-rich, glioma inactivated gene 1) is a candidate tumor suppressor gene for glioma and may play roles in other cancers. It belongs to a family of proteins with leucine-rich repeats (LRRs) similar to transmembrane signaling molecules and receptors. LGI1 acts as a ligand to ADAM22, a metalloprotease localized at the synapse. Mutations in LGI1 are associated with autosomal dominant lateral temporal epilepsy (ADTLE), characterized by focal seizures with auditory symptoms. Two isoforms of LGI1 are known.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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