Thermo Fisher Scientific ALK Monoclonal Antibody (OTI1A4)
ALK 단백질을 인식하는 마우스 단클론 항체로, Western blot, IHC, Luminex 등 다양한 응용에 적합합니다. 인간 ALK 단백질의 1300-1620 아미노산 구간을 항원으로 제작되었습니다. 액상 형태이며, 친화 크로마토그래피로 정제되었습니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:2,000 | |
| Immunohistochemistry (IHC) | Assay-dependent | |
| Luminex (LUM) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1A4 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1300–1620 of human ALK (NP_004295) produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol, 1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and is vital for brain development. Mutations, rearrangements, and amplifications in the ALK gene have been associated with tumors such as anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer. Chromosomal rearrangement often results in a fusion gene combining ALK and the nucleophosmin (NPM) gene. The NPM-ALK fusion product is oncogenic. ALK encodes a receptor tyrosine kinase with transmembrane and extracellular domains, showing high sequence similarity to LTK, and plays an important role in neuronal development.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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