Thermo Fisher Scientific Mouse LIF, Animal-Free Recombinant Protein, PeproTech
Mouse LIF 재조합 단백질로, 동물 유래 성분이 없는 고순도(≥98%) 제품입니다. 줄기세포 분화 억제 및 유지 연구에 적합하며, 생물학적 활성이 표준 대비 완전합니다. E. coli 발현, 19.6 kDa 크기, ≤0.05 ng/ml 활성 효능을 보유합니다.
- 카탈로그번호
- AF-250-02-xxxxx (2개 옵션)
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Mouse LIF, Animal-Free Recombinant Protein, PeproTech
Applications
Functional Assay (Functional)
- Assay-dependent
In vitro Assay (IV)
- Refer to publication
Miscellaneous PubMed (Misc)
- Refer to publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Mouse |
| Published Species | Mouse |
| Expression System | E. coli |
| Amino Acid Sequence | SPLPITPVNA TCAIRHPCHG NLMNQIKNQL AQLNGSANAL FISYYTAQGE PFPNNVEKLC APNMTDFPSF HGNGTEKTKL VELYRMVAYL SASLTNITRD QKVLNPTAVS LQVKLNATID VMRGLLSNVL CRLCNKYRVG HVDVPPVPDH SDKEAFQRKK LGCQLLGTYK QVISVVVQAF |
| Molecular Weight | 19.6 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 98% by SDS-PAGE gel and HPLC analyses |
| Endotoxin Concentration | < 0.1 EU/µg |
| Activity | Fully biologically active compared to standards. ED50 ≤ 0.05 ng/ml (≥ 2 × 10⁷ units/mg) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
Product Specific Information
Recombinant Murine LIF is a 19.9 kDa protein containing 180 amino acid residues, including three disulfide bonds.
This product is shipped at ambient temperature. For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis.
Target Information
Leukemia inhibitory factor (LIF) is a 20 kDa protein that belongs to the IL-6 receptor family. It binds to a heterodimeric membrane receptor composed of a LIF-specific subunit (gp190 or LIFR) and the shared subunit gp130.
LIF is expressed in various tissues such as thymus, lung, and neuronal tissue, and can be up-regulated by pro-inflammatory cytokines including TNFα and IL-17. Elevated levels are observed in rheumatoid arthritis, neural injury, systemic inflammation, and tuberculosis.
LIF is well known for inhibiting mouse embryonic stem cell differentiation and supporting stem cell self-renewal. Human and mouse LIF share 79% sequence homology with cross-species activity, though differentiation inhibition is mouse-specific.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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