Thermo Fisher Scientific USP16 Monoclonal Antibody (OTI1B4), TrueMAB

Applications

• Western Blot (WB): 1:200–1:4000

Product Specifications

Target Information

Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity.
An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families: ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs), OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes.
Among these families, USPs represent the most widespread deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from conjugated proteins and display conserved catalytic domains containing Cys and His boxes, with variable N-terminal or C-terminal extensions involved in substrate recognition, localization, and protein interactions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.