Thermo Fisher Scientific APC11 Polyclonal Antibody
APC11 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 사용 가능. 인간에 반응하며 항원 친화 크로마토그래피로 정제됨. 세포 주기 관련 E3 유비퀴틴 리가제 연구에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human APC11. Recombinant protein control fragment (Product #RP-93303). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2638063 |
Product Specific Information
Immunogen sequence:
SPWCLDHSCD LFGITDQVSA DGPRACRQGA RRRLPAGVGP VLPLLPHALH PQVAARTAGA AALPHVPPGM EVQGV
Highest antigen sequence identity to the following orthologs:
- Mouse: 30%
- Rat: 29%
Target Information
Together with the cullin protein ANAPC2, APC11 constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.
The APC/C complex mediates ubiquitination and subsequent degradation of target proteins, primarily forming Lys-11-linked polyubiquitin chains and, to a lesser extent, Lys-48 and Lys-63 chains. It may recruit E2 ubiquitin-conjugating enzymes to the complex. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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