Thermo Fisher Scientific DIABLO Recombinant Rabbit Monoclonal Antibody (001)
인간 SMAC/Diablo 단백질을 인식하는 재조합 토끼 단클론 항체로, 높은 특이성과 재현성을 제공합니다. 단백질 A로 정제된 보존제 무첨가 액상 형태이며, IP 등 다양한 응용에 적합합니다. 연구용으로만 사용 가능합니다.
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- MA529219
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- pk
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Applications
Immunoprecipitation (IP)
- Tested Dilution: 0.5–2 µL/mg of lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 001 |
| Immunogen | Recombinant Human SMAC/Diablo Protein (Ala56–Asp239) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2785127 |
Product Specific Information
This product is preservative-free. To prevent contamination, it is recommended to add sodium azide to a final concentration of 0.05%–0.1%.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and screened to select the best candidates for production.
Advantages of recombinant rabbit monoclonal antibodies:
- Excellent specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to the rabbit immune repertoire
This antibody specifically detects Human SMAC/Diablo.
Target Information
DIABLO (SMAC) is a mitochondrial protein that activates apoptosis by neutralizing members of the IAP family of apoptosis inhibitory proteins. During apoptotic events, Smac exits the mitochondria and enters the cytosol, facilitating mitochondrial-mediated apoptosis essential for normal development and tissue homeostasis.
Alterations in this pathway are associated with various malignancies. Smac/DIABLO also plays a key role in sensitizing cancer cells to apoptosis induced by immune or drug stimuli.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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