Thermo Fisher Scientific IL-29 Polyclonal Antibody

Thermo Fisher Scientific IL-29 Polyclonal Antibody

Applications

• Western Blot (WB)

Tested Dilution

• 1:500–1:1,000

Product Specifications

Product Specific Information

This product can be used in direct ELISA.

Target Information

IFN-lambdas constitute a novel family of interferons that mediate the induction of antiviral protection in a wide variety of cells. There are three members in this family, namely lambda1, lambda2, and lambda3, which are also known as IL-29, IL-28A, and IL-28B, respectively. Similar to type I IFNs, IFN-lambdas activate intracellular signaling to promote gene expression.

IFN-lambdas mediate their antiviral protection through a class II cytokine receptor complex composed of two essential receptor proteins, CRF2-12/IFN-lambdaR1 (unique to IFN-lambdas) and CFR2-4/IL-10R2 (shared with IL-10, IL-22, and IL-26 receptors).

IL-28 and IL-29 have been reported to prime dendritic cells to induce proliferation of Foxp3-bearing regulatory T cells. Dendritic cells that differentiate in response to IFN-lambdas express high levels of class I and II MHC gene products but low levels of costimulatory molecules. These cells can specifically induce IL-2-dependent proliferation of CD4+CD25+FOXP3+ T cells with contact-dependent suppressive activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.