Thermo Fisher Scientific CD20 Recombinant Rabbit Monoclonal Antibody (001)
Thermo Fisher CD20 Recombinant Rabbit Monoclonal Antibody (Clone 001)은 인간 CD20 단백질을 표적하는 고순도 재조합 항체입니다. Flow Cytometry에 최적화되어 있으며, HEK293 세포에서 발현된 Rabbit IgG 형식입니다. 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 1:25–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 001 |
| Immunogen | Human CD20 Transfected CHO Cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2866613 |
Additional Formats
Target Information
CD20 is a non-glycosylated surface phosphoprotein (33–37 kDa) expressed on mature and malignant B cells, a subset of T lymphocytes, and follicular dendritic cells. It regulates transmembrane calcium conductance, cell cycle progression, and B-cell proliferation.
CD20 associates with lipid rafts, with its intensity depending on extracellular triggers such as conformational changes or BCR aggregation. Upon receptor ligation, CD20 and BCR colocalize and then separate before endocytosis, with CD20 remaining on the cell surface.
CD20 is a key therapeutic target for antibody-mediated B-cell depletion in malignancies, as it remains membrane-bound after monoclonal antibody treatment.
Diseases associated with CD20 dysfunction include Ms4a1-related common variable immune deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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