Thermo Fisher Scientific Phospho-CHK2 (Ser516) Polyclonal Antibody
CHK2 단백질의 Ser516 인산화 부위를 인식하는 폴리클로날 항체로, 인간, 마우스, 랫트 시료에 반응합니다. Western blot과 ELISA에 적합하며, 액상 형태로 제공됩니다. DNA 손상 반응 및 세포주기 연구에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphorylated peptide around S516 of human Chk2 (NP_0091251) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.45 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901836 |
Product Specific Information
- Positive Samples: NIH/3T3
- Immunogen sequence: QPSTS
Target Information
CHEK2 (CHK2) is a serine/threonine kinase involved in the DNA damage checkpoint pathway. Mutations in CHK2 have been linked to various cancers. CHK2 is activated by DNA damage and phosphorylates several cell cycle control proteins, including tumor suppressors. It can also phosphorylate BRCA1, aiding in DNA damage recovery. Mutations in CHK2 are associated with Li-Fraumeni syndrome and may predispose individuals to sarcomas, breast cancer, and brain tumors.
주의사항
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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