Thermo Fisher Scientific NO66 Polyclonal Antibody
Thermo Fisher Scientific의 NO66 Polyclonal Antibody는 인간 단백질에 반응하며 Western blot에 적합합니다. NO66 산소화효소를 표적하며, 히스톤 탈메틸화 연구에 유용합니다. 염화나트륨 완충액(TBS) 기반의 액상 항체로, -20°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.3–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (GAQHSDSKDPR) corresponding to the internal amino acids of C14orf169 (aa 463–474) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10979300 |
Product Specific Information
- Predicted to react with mouse and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 1:64,000.
Target Information
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates Lys-4 (H3K4me) and Lys-36 (H3K36me) of histone H3, thereby playing a central role in histone code regulation.
Preferentially demethylates trimethylated H3 Lys-4 (H3K4me3) and monomethylated H3 Lys-4 (H3K4me1), with weaker activity for dimethylated H3 Lys-36 (H3K36me2).
Also catalyzes the hydroxylation of 60S ribosomal protein L8 on His-216.
Acts as a regulator of osteoblast differentiation via interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation.
May also play a role in ribosome biogenesis and chromatin remodeling, and participates in MYC-induced transcriptional activation.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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