Thermo Fisher Scientific MHC Class II Monoclonal Antibody (PF6J-6D)

Applications

• Western Blot (WB): Assay-dependent
• Immunohistochemistry (Paraffin) (IHC (P)): Assay-dependent
• Flow Cytometry (Flow): Assay-dependent
• ELISA (ELISA): Assay-dependent

Product Specifications

Product Specific Information

This antibody recognizes an epitope within the beta chain region of cat MHC class II molecules which are expressed by antigen presenting cells, B cells, monocytes, and activated T lymphocytes.

Target Information

MHC (major histocompatibility complex) class II molecules are transmembrane glycoproteins expressed on the surface of professional antigen-presenting cells such as macrophages, dendritic cells, and B cells. Before their exposition on the cell surface, the MHC class II molecules react with endocytosed exogenous antigens, which are then presented to T cells.
The antigen-binding groove between MHC class II alpha and beta chain is open at both ends and is 15–24 amino acid residues long.

HLA and MHC antibodies play a significant role in immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem mass spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.