Thermo Fisher Scientific PCID2 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human PCID2 protein. Validated for ICC/IF applications with high specificity. Suitable for studying B-cell survival and TREX-2 complex function. Supplied in liquid form with PBS buffer and glycerol for stability.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human PCID2. Recombinant protein control fragment (Product # RP-107905) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2663527 |
Product Specific Information
Immunogen sequence:
VCASDTRAGIE DSKKWGMLFL VNQLFKIYFK INKLHLCKPL IRAIDSSNLK DDYSTAQRVT YKYYVGRKAM FDS
Highest antigen sequence identity to the following orthologs:
- Mouse: 99%
- Rat: 100%
Target Information
Required for B-cell survival through regulation of MAD2L1 expression during B cell differentiation.
Component of the TREX-2 complex (transcription and export complex 2), including ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388).
The TREX-2 complex docks export-competent ribonucleoprotein particles (mRNPs) to the nuclear pore complex and participates in mRNA export and chromatin positioning.
PCID2 binds and stabilizes BRCA2, contributing to the control of R-loop-associated DNA damage and transcription-related genomic stability.
R-loop accumulation does not increase in PCID2-depleted cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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