Thermo Fisher Scientific Sclerostin Polyclonal Antibody
Rabbit polyclonal antibody targeting human Sclerostin (SOST), validated for WB, IHC(P), and ICC/IF. Detects endogenous total SOST. Supplied as liquid, unconjugated form, 1 mg/mL in PBS with glycerol. Ideal for bone metabolism and Wnt signaling research.
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- PA599860
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human SOST (Accession Q9BQB4), corresponding to amino acid residues K30–C80 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818793 |
Product Specific Information
Antibody detects endogenous levels of total SOST.
Target Information
Sclerostin is a glycoprotein predominantly secreted by osteocytes and a member of the Cerberus/DAN family of BMP antagonists. It acts as an endogenous regulator of the canonical Wnt signaling pathway and inhibits bone homeostasis. Although mainly expressed in osteocytes, sclerostin is also found in bone, bone marrow, cartilage, kidney, and liver, and is produced by hypertrophic chondrocytes and cementocytes.
Sclerostin forms inhibitory complexes with LRP5 and LRP6, co-receptors essential for Wnt/beta-catenin signaling. It also interacts directly with LRP4 to facilitate inhibition of Wnt signaling and promotes osteoclast activity by increasing RANKL expression.
Deficiency or mutation of sclerostin leads to disorders such as sclerosteosis and van Buchem disease, characterized by excessive bone formation and hypermineralization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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