Thermo Fisher Scientific ABHD4 Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 1.0 µg/mL

Product Specifications

Product Specific Information

This target displays homology in the following species:
Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Target Information

The α/β hydrolase superfamily is comprised of diverse members involved in important biochemical processes and various diseases. Despite having unrelated sequences and different substrates, they share the canonical α/β hydrolase fold consisting of an eight-stranded parallel α/β structure and a catalytic triad composed of a histidine, an acid, and a nucleophile.

Members of this superfamily are often drug targets for treating diseases such as diabetes, Alzheimer’s disease, obesity, and blood clotting disorders.

• ABHD1: Metabolizes smoking xenobiotics
• ABHD2: Participates in the development of atherosclerosis
• ABHD4: Involved in an alternative synthesis pathway of NAE; lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE) participating in biosynthesis of N-acyl ethanolamines
• ABHD5: Mutations contribute to Chanarin-Dorfman syndrome
• ABDH6: May play a role in nervous system metabolism and signaling
• ABHD14A: Possibly involved in granule neuron development

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.