Thermo Fisher Scientific PKP2 Polyclonal Antibody
PKP2 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot, IHC(P), ICC/IF에 사용 가능. Human 시료 반응성. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol buffer에 보존. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 | – |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | – |
Product Specifications
| Category | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PKP2. Recombinant protein control fragment (Product # RP-89628). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2645606 |
Product Specific Information
Immunogen sequence:
VGNGNLHRTS SVPEYVYNLH LVENDFVGGR SPVPKTYDML KAGTTATYEG RWGRGTAQYS SQKSVEERSL RHPLRRLEIS PDSSPERAHY THSDYQYSQR SQAGHTLHHQ ESRRAALLVP PRY
Highest antigen sequence identity to orthologs:
- Mouse: 65%
- Rat: 41%
Target Information
Plakophilins (PKP1–4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments.
They contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes, which are junctions found in suprabasal layers of stratifying epithelia under mechanical stress.
- Plakophilin 1: Mediates increases in desmosomal protein content, desmosome assembly, and regulation of cell migration.
- Plakophilin 2: Important for desmosome assembly and acts as an essential morphogenic factor and structural component of the heart.
- Plakophilin 4: Component of desmosomal adhesion plaques that regulates junctional plaque organization and cadherin function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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